Serum betatrophin levels and fatty acid profile in gestational diabetes mellitus: Correlation with insulin resistance

Introduction and Aim: Gestational diabetes mellitus (GDM) involves insulin resistance, altered levels of adipocytokines inflammation. Interaction various molecules in the pathogenesis obesity resistance plays a major role GDM. Angiopoietin-like protein 8, also named betatrophin is hormone which synthesized from liver adipocytes. This molecule has beta cell-regenerating effect proposed to have therapeutic potential obesity, mellitus. The present study aimed evaluate free fatty acids (FFA) as markers gestational (GDM). Materials Methods: was conducted Medical College Hospital on pregnant women with normal body mass index. subjects were divided into 2 groups -one healthy other GDM recruited for at 24 28 weeks gestation. betatrophin, FFA estimated serum HOMA-IR calculated. Results: Insulin (IR), level plasma omega-6 acid higher, omega-3 lower among comparison women. Fasting glucose, dihomo gamma linolenic showed significant positive correlation IR while omega 3 %, alpha acid, lauric negative Conclusion: Altered profile indicated application biomarkers metabolic derangements arise due resistance. findings diagnostic, prognostic, implications.